Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

ED50 = 30 nM in protecting etoposide-induced cortical neuron death

Cell permeable: yes

Primary Targetp53

General description

A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED₅₀ = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t_1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152).

A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED₅₀ = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t_1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pietrancosta, N., et al. 2006. J. Med. Chem.49, 3645.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)